SIAT Research
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Mar 14, 2023Scientists Develop Magnetic-Acoustic Actuated CAR-T Cell Robots for Precision Antitumor ImmunotherapyIn this strategy, a living CAR T cell microrobot based on magnetic-acoustic sequential actuation for self-controllable targeting and augmented antitumor immunotherapy in solid tumor by artificially... Although chimeric antigen receptor (CAR) T cell therapy has shown incredible success in the treatment of haematological malignancies, its application in solid tumors is unsatisfactory owing to the ... -
Mar 09, 2023Researchers Revealed Molecular Mechanism of Pannexin 2 as an ATP Membrane Pore Channel"Our work illuminated the 3D structures of Panx2 transmembrane protein at the atomic level,"said Prof. YUAN, "it helps to understand the fundamentally biological function of Panx2 which provides an... Recently, a research team collaborated by Prof. YUAN Shuguang from Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences and Prof. ZHANG Huawei from the South University of Science... -
Feb 23, 2023Twin-bioengine Self-adaptive Micro/nanorobots Developed for Gastrointestinal Inflammation Therapy"The transport route is similar to that of the Express Mail Service, which precisely delivers parcels to a distant destination using different transportation facilities," said Prof. CAI. These self... Micro/nanorobots with self-propelling and -navigating capabilities have attracted extensive attention in drug delivery and therapy owing to their controllable locomotion in hard-to-reach body tissu... -
Feb 07, 2023Deep Multi-Magnification Similarity Learning for Histopathological DiagnosisThe team proposed a novel deep multi-magnification similarity learning (DSML) approach that can be useful for the interpretation of multi-magnification learning framework and easy to visualize feat... Precise classification of histopathological images is the ultimate objective of the image analysis.In actual clinical applications, pathologists usually combine information at different magnificati... -
Feb 06, 2023Subtype-specificity in Sleep Regulation in DrosophilaThe team published this study entitled "Subtype-specific roles of ellipsoid body ring neurons in sleep regulation in Drosophila" in the Journal of Neuroscience as the cover/featured article The coherence of regulation of sleep by different brain regions and nuclei in mammals is complex. The ellipsoid body (EB), as a major structure of the central complex of the Drosophila melanogaster... -
Jan 10, 2023Genetically Engineered Bacterium Enables Biosynthesis of Melanin Nanoparticles"This study provides a rationale for the biomedical applications of biosynthetic melanin nanoparticles," said Prof. YAN Fei, "and encourages other researchers to produce nanomaterials by microorgan... Photothermal therapy (PTT) has attracted considerable attention for tumor treatment due to its unique advantages in minimal invasiveness and spatiotemporal selectivity.Melanin is a kind of multifun... -
Dec 26, 2022Mapping the Neural Circuitry of Predator Fear in the Nonhuman PrimateThis work was awarded 'Editors' Choice', an award given by the Nature-Springer Group and the journal Brain Structure and Function during the Cajal Club at the Society for Neuroscience conference 2023. The innate fear networks are becoming better known in rodents, with major discoveries having been made in the last decade. But to really exploit them, we need to compare these networks between rode... -
Dec 26, 2022Successful Hypothermia in Nonhuman Primate Paves the Way for Future Application in Human TorporThe team has recently reported the first reliable hypothermia in nonhuman primates caused by activating a group of hypothalamic neurons. Hibernation is a state adopted by certain mammals as an adaptation to adverse winter conditions. Typical features of hibernation include greatly reduced metabolic activity and lowered body temperat...