SIAT Research
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May 14, 2025Genomic Evolution Reshapes Cell-type Diversification in the Amniote BrainThe researchers have constructed a cross-species single-nucleus RNA-seq atlas of amniote brains comprising over 1.3 million cells, uncovering conserved and divergent cell-type evolution. Recently, a research team led by Prof. LIU Shiping and Prof. XU Xun of BGI Research Hangzhou, Prof. WANG Zhenlong of Zhengzhou University, Prof. XU Chun of the Institute of Neuroscience of the Chin... -
May 13, 2025Researchers Uncover Neural Circuit Mechanism behind Individual Differences in Innate FearElucidating the neural circuitry underlying innate fear not only enhances our understanding of emotional disorders but also provides promising therapeutic targets for clinical interventions. In a study published in Neuron on May 9, a research team led by Prof. WANG Liping from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences, has revealed the neu... -
May 12, 2025Winning Experiences Reduce Drug-Seeking Behavior by Reshaping the Brain's Dopamine SystemThe findings reveal that social dominance alters the balance between two key dopamine pathways: the mesolimbic and mesocortical pathways. In a study published in Nature Neuroscience on May 12, a research team led by Prof. ZHU Yingjie at the Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, has uncovered ... -
Apr 27, 2025Researchers Reveal Reciprocal Interaction between Extrachromosomal DNA Maintenance and DNA Damage ResponseNew study reveal a reciprocal regulatory relationship between extrachromosomal DNA (ecDNA) maintenance and the DNA damage response (DDR). Extrachromosomal DNA (ecDNA) is a unique form of circular DNA that exists outside of normal chromosomes. Found exclusively in tumor cells, it often carries cancer-promoting genes (oncogenes) and is... -
Apr 24, 2025Oscillating Microbubble Array-based Metamaterials (OMAMs) for Rapid Isolation of High-Purity ExosomesCompared to existing methods, the OMAMs platform offers a significantly faster, simpler, and potentially more cost-effective route to obtaining high-purity exosomes directly from clinical samples. ... Exosomes, secreted by most cells, carry biological information and proteins that serve as noninvasive biomarkers for diagnosing and predicting disease progression and metastasis. However, the rapid... -
Apr 17, 2025Living Hydrogel-based Miniaturized and Portable Bio-battery for Precise Nerve StimulationResearchers develop a miniaturized, portable bio-battery measuring 20 millimeters in diameter and 3.2 millimeters in height. This innovative device integrates a bioelectric stimulation mechanism, e... A research team led by ZHONG Chao, LIU Zhiyuan, and WANG Xinyu from the Shenzhen Institutes of Advanced Technology (SIAT) of Chinese Academy of Sciences, in collaboration with WANG Renheng from She... -
Apr 14, 2025Head-Mounted Microscope Reveals High-Resolution Neurovascular Dynamics in Freely Behaving MiceThe microscope, for the first time, enables dual-modal imaging at high spatiotemporal resolution, enhancing our understanding of neurovascular coupling mechanisms without affecting the natural beha... A research team led by Prof. LIU Chengbo from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences, has developed a groundbreaking 1.7-gram head-mounted microsco... -
Apr 08, 2025Newly Discovered PNS Microglia Found to Regulate Neuron SizeThe key finding of the study is that PNS microglia share a common molecular signature, protein marker, epigenetic profile, and ontogenetic trajectory with the CNS microglia in humans. This finding ... In a study published in Cell on April 7, a research team led by Prof. LI Hanjie from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences has revealed the presen...