SIAT Research
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Dec 07, 2022New Strategy Enables Targeted Degradation of Extracellular and Membrane-associated ProteinsAs demonstrated in the development of BMS-L1-RGD, which is an efficient programmed death-ligand 1 (PD-L1) degrader validated both in vitro and in vivo, the IFLD strategy expands the toolbox for reg... Targeted protein degradation (TPD) technologies including the traditional proteolysis targeting chimeras (PROTACs), the recently reported lysosome-targeting chimeras (LYTACs) and related technologi... -
Dec 06, 2022Phase Separation of Scaffold Protein Regulates Microbial Asymmetric Cell DivisionThe team proposed that the PodJ scaffold in the new cell pole forms biomolecular condensates with physiological functions via phase separation, which helps to establish and regulate the asymmetry o... By polarizing different cell fate determinants at opposite cell poles, asymmetric cell division (ACD) that produces distinct daughter cells is an evolutionarily conserved mechanism to generate cell... -
Nov 25, 2022How Much Water Do We Need a Day?"The main outcome of our study was a general equation for predicting water turnover. This will help countries anticipate their future water needs," said Prof. Speakman. A new study led by Prof. John Speakman from the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences (CAS) and the University of Aberdeen shows that the recommended w... -
Nov 14, 2022Hybridization of Surface Lattice Resonances Induces Dual-Band Bound States in the ContinuumThe researchers expected that this concept will help to suppress the inherent losses and to achieve high Q-factors for plasmonic metasurfaces, on which they finished the experimental demonstration ... High quality factors (Q-factors) are favorable in a diverse range of applications, ranging from photoluminance, lasers, nonlinear optics, strong coupling, and optical sensing. In metasurfaces, surf... -
Nov 14, 2022Researchers Reveal How Nucleus Accumbens Mediates Positive and Negative Motivational ValenceReward-seeking and threat avoidance are critical for survival. Pursuing enjoyable things triggers the release of dopamine in the brain, making people feel pleasure. On the contrary, people subconsc... -
Nov 14, 2022Researchers Predict Unseen Antibodies Neutralizability via Adaptive GnnsThe proposed DeepAAI learns unseen antibody representation by constructing two adaptive relation graphs among antibodies/antigens and applying Laplacian smoothing between unseen and seen antibodies... Antibodies (Abs) opsonize and neutralize viruses, working as potent bio-pharmaceuticals in clinical treatments for their high specificity and affinity to antigens. However, most natural and synthet... -
Nov 07, 2022Synthetic Energy Metabolism Enables Twin Engine for Cell"Energy metabolic reprogramming demonstrates that despite extensive regulation of catabolism in yeast, it is still possible to rewire their energy metabolism," said Prof. YU. A research team led by Prof. YU Tao from the Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, has proposed a novel synthetic energy system that supports yeast cell growth and... -
Oct 28, 2022Researchers Design Soil-inspired Multifunctional Chemical System"The system is chemically, optically, and mechanically responsive with programmable properties," said Prof. LIN Yiliang, corresponding and first author of this study and currently an assistant prof... Soil is a dynamic system of microbe-material interactions and environmental responsiveness. The soil-microbe complex is an integrated and adaptable system that can reshape its state according to th...