SIAT Research
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Apr 12, 2022Researchers Develop New Strategy for Genetically Engineering Stem CellsThis study adapted a stem cell-mediated gene therapy (MSC-GT) strategy and applied it in bone regeneration, in which BMP2 genetically modified MSCs function as cellular factories. Stem cell therapy has been widely applied for tissue regeneration. Recently, stem cell-derived exosomes (MSC-Exo) have attracted significant interest for their “cell-free” therapies. Therefore, i... -
Apr 01, 2022C/EBPβ/AEP Pathway Dictates Both Alzheimer's Disease and Longevity: StudyThis finding expands this pathway's function beyond the control of AD pathologies to the regulation of life span. Cognitive decline during normal aging is exacerbated in neurodegenerative disease including Alzheimer's disease (AD). While it is not yet known exactly what causes AD, there are a number of risk fa... -
Mar 29, 2022Researchers Reveal VTA→BLA Dopamine Neurons Selectively Control Anxiety-Related Behaviors in Singular Anxiety or Comorbid Anxiety-Depression ConditionsThis study provides new insight into the functional role of VTA→BLA dopamine neurons in selective regulation of anxiety-related behaviors, and provides important information for developing a brain... Anxiety disorders are the most common psychiatric illnesses, afflicting 273 million people worldwide. A substantial number of patients suffering from anxiety disorders also display depressive-like ... -
Mar 23, 2022Researchers Reveal Neuronal Mechanism Controlling Anxiety-Like Behavior and Energy ExpenditureResearchers found enhanced burst firing in the dmVMH after chronic stress, and the strength of the burst firing was correlated with anxiety-like behavior. Optogenetically evoked burst firing in dmV... Stress responses including physiological and behavioral changes facilitate threat avoidance. Long-term stress affects normal brain function and induces both anxiety and glucose or lipid metabolism ... -
Mar 21, 2022Sea-Trial Research on Natural Product-Based Antifouling Paint Applied to Underwater Sensor Housing Materials"It is worth noting that the CPT-based paint also has great potential for other artificial submerged structures in the marine environment, such as ship hulls, oil platforms and aquaculture faciliti... Biofouling is a common challenge for underwater sensors, especially for long-term in situ monitoring in marine environments. Biofouling on in situ sensor surfaces can shorten their operating lifeti... -
Mar 15, 2022Researchers Propose a Boundary-Aware Context Neural Network for the Medical Image SegmentationThe proposed method has been quantitatively and qualitatively validated in various lesion segmentation tasks of multi-modal medical images, such as dermoscopy images, endoscope images, and X-ray im... Automatic detection and recognition of lesions in medical images through artificial intelligence algorithms provides an economic, efficient, and effective computer-aided approach for clinical diagn... -
Mar 15, 2022Live Fast, Die Young? or Live Cold, Die Old?Based on these results, body temperature seems to be a much more important mediator of lifespan than metabolic rate. For this reason, maybe we should change the saying from "live fast, die young" t... Researchers from the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences, along with collaborators from Wenzhou University and the University of Aberdeen, have found... -
Mar 04, 2022Researcher Develop New Synthetic Genetic Circuits for Prefect Adaptation FunctionThis study addresses the serious problems of poor stability, functional fragility and susceptibility to interference of synthetic genetic circuits in synthetic biology, and proposes the principle o... Since the sophisticated genetic circuits can be very subtle, external environmental variability and host evolutionary instability have emerged as key factors impeding the predictable design of gene...