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REN Peigen

Date：25-07-2017   |   【Print】 【close】

REN Peigen

Education  

1991.9–1996.7  Department of Veterinary Medicine, Inner Mongolia Agriculture University, Huhehot,China - B.Sc. awarded on Veterinary Medicine 

1996.9–1999.7   Institute of Veterinary Medicine, Chinese Academy of Agriculture Sciences (CAAS), Beijing, China. Master of Science awardedon Veterinary Medicine/Molecular Viral Epidemiology. Supervisor: Professor QG Xie. 

1999.9–2004.7   Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China. Ph.D awarded.onMicrobiology. Supervisor: Professor PG Zhou. 

2000.8–2001.10   Microbe Division (JCM), RIKEN, Wako, Saitama Prefecture, Japan. Visiting scholar/Ph.D candidate. On: Microbiota ecology of human GI tract. Supervisor: Dr. Benno Y. 

          

Professional Experience (in chronological order) 

2012.9-Present   Translational Medicine R & D Center, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Techonology, CAS. Professor. 

2010.12-2012.9   Translational Medicine R & D Center, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Techonology, CAS. Associate professor. 

2009.9–2010.12  Orthopaedics Surgery Dept., Medical Center, Stanford University, Stanford, California. Research associate 

2006.9–2009.9   Orthopaedics Surgery Dept., Medical Center, Stanford University, Stanford, California. Postdoctoral research scholar 

2004.8–2006.9   OB/GYN Dept., Medical Center, Stanford University, Stanford, California as Postdoctoral research scholar.研究领域ResearchInterests 

  

Representative Publications 

  1. Effect of High-fat Diet on Genome-wide Profiles in Ovary and White Adipose Tissue of Immature Female Mice. Scientific Reports. (Submitted) 
  2. Xiang L, Jiang XT, Huang C, Li J, Chen J, Yan DW, Ren P-G*, Zhang J*. CMKLR1 deficiency leads to bone loss in male mice. J Endocrinol. 2017. (Submitted) 
  3. Xue L, Yu Y, Tang HR, Xiang L, Chen J, Xiao TX, Ren P-G*, Zhang J*. Alleviation of high-fat-diet-induced fat accumulation and fatty liver damage by a small molecule CMKLR1 antagonist in mice. J Endocrinol Invest. 2017. (Submitted) 
  4. Li J#, Xiang L#, Jiang XT, Teng B, Sun YT, Chen GL, Chen J, Zhang JV*, Ren P-G*. Investigation of bioeffects of GPR1 on bone turnover in male mice. J Orthop. Translat. 2017. (Under publication) 
  5. Li J, She C, Yao Z-Y, Li J, Teng B, Lin S-B, Dong Q-R*, Ren P-G*. Effects of low-dose X-ray irradiation on activated macrophages and their possible signal pathways. PlosOne. 2017. (Revised, under review) 
  6. Li J, Jahr H, Zheng W, Ren P-G*. Visualizing angiogenesis by multiphoton microscopy in vivo in genetically modified 3D-PLGA/nHAp scaffold for calvarial critical bone defect repaired. JoVE. 2017. (Accepted) (IF=1.19，JCR 2区) 
  7. Li J#, Xu Q#, Teng B, Yu C, Li J, Song L, Lai YX, Zhang J, Zheng W*, Ren P-G*.Investigation of angiogenesis by in vivomultiphoton microscopy during bone-formation in murine calvarial critical bone defect repaired by genetically modificated 3D-LGA/nHAp scaffold. ActaBiomaterialia. 2016. 42: 389-99. (IF=6.025，JCR 1区) 
  8. Yang Y-L*, Ren L-R*, Sun L-F*, Huang C, Xiao T-X, Wang B-B, Chen J, Zabel BA, Ren P-G#, Zhang JV#. The role of GPR1 signaling in mice corpus luteum. J Endocrinol. 2016. 230(1): 55-65. (IF=4.498，JCR 1区) 
  9. Li J, Teng B, Lin RQ, She C, Yao ZY, Zhang J, Song L*, Ren P-G*. Neovasculature in 3D-PLGA/nHAp Scaffolds for Murine Critical sized Bone Defect Regeneration by Photoacoustic Imaging: A Preliminary Study. International Advanced Research Journal in Science, Engineering and Technology (IARJSET). 2016. 3(4):162-70. (IF=3.943，JCR 2区) 
  10. Huang C, Wang MM, Ren LR, Xiang L, Chen J, Li MX, Xiao TX, Ren P-G, Xiong LK, Zhang JV. CMKLR1 deficiency influences glucose tolerance and thermogenesis in mice on high fat diet. Biochemical and Biophysical Research Communications (BBRC). 2016. 473(2): 435-41. (IF=2.371，JCR 3区) 
  11. She C, Shi GL, Xu W, Zhou XZ, Li J, Tian Y, Li J, Li WH, Dong QR*, Ren P-G*. Effect of low-dose X-ray irradiation and Ti particles on the osseointegration of prosthetic. J Orthop Res. 2016. 34(4):725-8. (IF=2.807，JCR 1区) 
  12. Tang M, Huang C, Wang Y-F, Ren P-G, Chen L, Xiao T-X, Wang B-B, Pan Y-F, Tsang BK, Zabel BA, Ma B-H, Zhao H-Y, Zhang JV. CMKLR1 deficiency maintains ovarian steroid production in mice treated chronically with dihydrotestosterone. Scientific Reports. 2016. (Epub Ahead). (IF=5.228，JCR 1区) 
  13. Guo CZ, Li J, She C, Shao XZ, Teng B, Feng J, Zhang JV, Ren P-G. Bioeffects of Micron-Size Magnesium Particles on Inflammatory Cells and Bone Turnover In vivo and In vitro. J Biomed Mater Res B. 2016.104(5):923-31. (IF=2.33，JCR2区) 
  14. She C, Xu W, Shi GL, Zhou XZ, Li J, Guo CZ, Chen M, Keng Y-K, Ren P-G*, Dong QR*. The effect of low dose-X-ray radiation on the bone ingrowth onto prosthesis interface. J OrthopTranslat. 2015. 2(4): 231-232. 
  15. Goodman SB, Gibon E, Pajarinen J, Lin TH, Keeney M, Ren P-G, Nich C, Yao Z, Egashira K, Yang F, Konttinen YT. Novel biological strategies for treatment of wear particle-induced periprostheticosteolysis of orthopaedic implants for joint replacement. J R Soc Interface. 2014. 11(93). (IF=3.818，JCR 1区) 
  16. Li L, Ma P, Huang C, Liu Y, Zhang Y, Gao C, Xiao T, Ren P-G, Zabel BA, Zhang JV. Expression of chemerin and its receptors in rat testes and its action on testosterone secretion.J Endocrinol. 2014. 220(2):155-63. (IF=4.498，JCR 1区) 
  17. Zhang JV, Li L, Huang QS, Ren P-G, Obestatin receptor in energy homeostasis and obesity pathogenesis.2013.ProgMolBiolTransl Sci. 114:89-107. (IF=3.364，JCR 2区) 
  18. Jawad U, Fritton K, Ren P-G, Ma T, Gambhir S, Goodman SB. Effects of Sclerostin Antibody on Healing of a Non-critical Size Femoral Bone Defect. 2013. J Orthop Res. 31(1): 155-63.（IF=2.807，JCR 1区） 
  19. Fritton K, Ren P-G*, Gibon E, Rao A, Ma T, Biswal S, Gambhir S, Goodman SB. Exogenous MC3T3 Pre-osteoblasts Migrate Systemically and Mitigate the Adverse Effects of Wear Particles. 2012. Tissue Engineering.18(23-24): 2559-67. (*:Co-first author.) (IF=3.892，JCR 2区) 
  20. Gibon E, Ma T, Ren P-G, Fritton K, Biswal S, Yao Z, Smith L, Goodman SB. Selective inhibition of the MCP-1-CCR2 ligand-receptor axis decreases systemic trafficking of macrophages in the presence of UHMWPE particles. 2012. J Orthop Res. 30(4):547-53.（IF=2.807，JCR 1区） 
  21. Fan XJ, Ren P-G, Dhal S, Bejerano G, Goodman SB, Druzin ML, Gambhir SS, and Nayak NR. Noninvasive Monitoring of Placenta-Specific Transgene Expression by Bioluminescence Imaging. 2011. PlosOne. 6(1):e16348. (IF=3.057, JCR 1区) 
  22. Ren P-G, Irani A, Huang ZN, Ma T, Biswal S, Smith RL, Goodman SB. Continuous Infusion of UHMWPE Particles Induces Systemic Macrophage Trafficking and Osteolysis. ClinOrthopRelat Res. 2011. 469(1):113-22. (IF=3.127, JCR 1 区) 
  23. Wang B, Lü GH, Patel AA, Ren P-G, Cheng I. An evaluation of the learning curve for a complex surgical technique: the full endoscopic interlaminar approach for lumbar disc herniations. 2011. Spine J. 11(2): 122-130. (IF=2.660，JCR 1 区) 
  24. Huang ZN, Ren P-G, Ma T, Smith RL, Goodman SB. Modulating osteogenesis of mesenchymal stem cells by modifying growth factor availability. Cytokine. 2010. 51(3):305-10. (IF=2.940，JCR 2区) 
  25. Huang ZN, Ma T, Ren P-G, Smith RL, Goodman SB. Effects of orthopaedic polymer particles on chemotaxis of macrophages and mesenchymal stem cells. J Biomed Mater Res A. 2010, 94(4):1264-9. (IF=3.263，JCR 1区) 
  26. Ren P-G, Huang ZN, Ma T, Biswal S, Smith RL, Goodman SB. Surveillance of systemic trafficking of macrophages induced by UHMWPE particles in nude mice by non-invasive imaging. J Biomed Mater Res A. 2010. 94(3):706-11. (IF=3.263，JCR 1区) 
  27. Ma T, Ortiz SG, Huang Z, Ren P-G, Smith RL, Goodman SB. In vivo murine model of continuous intramedullary infusion of particles--a preliminary study. J Biomed Mater Res B., 2009. 88B(1): 250-253. (IF=3.33，JCR 2区) 
  28. Ma T, Ren P-G, Larsen DM, Suenaga E, Zilber S, Genovese M, Smith RL, Goodman SB. Efficacy of a p38 mitogen activated protein kinase inhibitor in mitigating an established inflammatory reaction to polyethylene particles in vivo. J Biomed Mater Res A., 2008. 89(1):117-23. (IF=3.263，JCR 1区) 
  29. Ren P-G, Lee S-W, Biswal S, Goodman SB. Systemic trafficking of macrophages induced by bone cement particles in nude mice. Biomaterials, 2008. 29: 4760-4765. (IF=8.387，JCR 1区) 
  30. Xue Y, Ventosa A, Wang X, Ren P-G, Zhou P, Ma Y. Bacillus aidingensis sp. nov., a moderately halophilic bacterium isolated from Ai-Ding salt lake in China.Int J SystEvolMicrobiol., 2008. 58(12): 2828-32. (IF=2.439，JCR 3区) 
  31. Ma T, Huang ZN, Ren P-G, Smith RL, Goodman SB. An In Vivo Murine Model of Continuous Intramedullary Infusion of Polyethylene Particles. Biomaterials, 2008. 29(27): 3738-42. (IF=8.387，JCR 1区) 
  32. Ren P-G, Ma T, Huang ZN, Smith RL, Goodman SB. Quantitation of bone area in undecalcified frozen sections with fluorescent microscopy. J Histotechnology, 2008. 31(1): 15-18. (IF=0.086，JCR 4区) 
  33. Huang Z, Ryu W, Ren P-G, Fasching R, Goodman SB. Controlled Release of Growth Factors on Allograft Bone in Vitro. ClinOrthopRelat Res., 2008. 466(8): 1905-11. (IF=3.127, JCR 1 区) 
  34. Zhang JV, Klein C, Ren P-G, Kass S, VerDonck L, Moechars D, Hsueh AJW. Response to Comment on “Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake”. Science, 2007. 315: 766d. (IF=34.661，JCR 1区) 
  35. Yuan S., Ren P-G, Liu J., Xue Y., Ma Y., and Zhou P.  Lentibacillushaloduranssp. nov., a moderately halophilic bacterium isolated from a salt lake in Xin-Jiang, China. Int J SystEvolMicrobiol., 2007. 57(3): 485 - 488. (IF=2.439，JCR 3区) 
  36. Zhang JV, Ren P-G, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C, Hsueh AJ. Obestatin, a peptide encoded by the Ghrelin gene, opposes ghrein’s effects on food intake. Science, 2005. 310: 996-9. (IF=34.661，JCR 1区) 
  37. Xu X.-W., Ren P-G, Liu S.-J., Wu M, Zhou P.-J. Natrinemaaltunense sp. nov., an extremely halophilicarchaeon isolated from a salt lake in Altun Mountain in Xinjiang, China. Int J SystEvolMicrobiol., 2005. 55: 1311-4. (IF=2.439，JCR 3区) 
  38. Ren, P-G& Zhou, P.-J. Salinibacillusaidingensis gen. nov., sp. nov.andSalinibacilluskushneri sp. nov., moderately halophilic bacteria isolated from a neutral saline lake in Xin-Jiang, China. Int J SystEvolMicrobiol., 2005. 55: 949-53. (IF=2.439，JCR 3区) 
  39. Ren, P-G& Zhou, P.-J. Tenuibacillusmultivorans gen. nov., sp. nov., a moderately halophilic bacterium isolated from saline soil in Xin-Jiang, China. Int J SystEvolMicrobiol., 2005. 55: 95-9. (IF=2.439，JCR 3区) 

  

RESEAECH INTERESTINGS 

Tissue engineering： Bone regeneration is important for healing of fractures and other diseases with bone loss. Tissue engineering is an effective method in bone repairing by using osteoprogenitor cells (BMSCs), 3D-scaffold. In my lab, we focus on the mechanisms and applications of biodegradable magnesium material as scaffold for bone regeneration.  

Peptide ligands and G protein-coupled receptors (GPCRs): These receptors play critical physiological roles and the dysfunction of them will result in diseases. Peptides are one group of major ligands of GPCRs. Out of the candidates, we just find a small molecular peptide which can induce beta-cell to produce more insulin. We are looking for the bio-functions of the new peptide in different tissues and system, and also trying to disclose the mechanisms of the peptide and its potential receptor/receptors. 

   

  

Email & Phone 

E-mail:pg.ren@siat.ac.cn 

Phone: 0755-86392289 

  

Website 

http://people.gucas.ac.cn/~renpeigen 

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