LI Hongchang

Date:29-07-2017   |   【Print】 【close


Hongchang Li, graduated from Beijing Normal University with bachelor degree in 1999, obtained a PhD degree from Institute of Genetics and Developmental Biology, Chinese Academy of Sciences in 2006, worked as a postdoctoral fellow at Purdue University between 2006 and 2010,returned to China as a faculty member at West China Developmental & Stem Cell Institute,Sichuan University in 2010,joined in Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences in 2011.  


Research intresests 

Cancer signaling pathways, cell division control, and antitumor drug discovery   



Shenzhen Peacock Talent 


Representive publications 

1)Jianchao Zhang, Ximing Shao, Haiyan Sun, Ke Liu, Zhihao Ding, Juntao Chen, Lijing Fang, Wu Su, Yang Hong, Huashun Li* and Hongchang Li*. (2016) NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling. Oncotarget, 7(38):61036-53   

2)Run Lei , Ke Zhang , Ke Liu, Ximing Shao, Zhihao Ding, Fudi Wang, Yang Hong, Minyan Zhu, Hongchang Li,* and Huashun Li*. (2016) Transferrin Receptor Facilitates TGF- and BMP Signaling Activation to Control Craniofacial Morphogenesis. Cell death and Disease, Jun 30;7(6):e2282 

3)Ximing Shao, Yi Liu, Qian Yu, Zhihao Ding, Wenyu Qian, Lei Zhang, Jianchao Zhang, Nan Jiang, Linfei Gui, Zhiheng Xu, Yang Hong, Yifan Ma, Yanjie Wei, Xiaoqing Liu, Changan Jiang, Minyan Zhu, Hongchang Li* & Huashun Li*. (2016) Numb Regulates Vesicular Docking for Homotypic Fusion of Early Endosomes via Membrane Recruitment of Mon1b. Cell Research, 26(5):593-612  

4)Run Lei, Ke Zhang,Yanxia Wei,Min Chen,LeeS.Weinstein,Yang Hong, Minyan Zhu, Hongchang Li*,Huashun Li*. (2016) G-Protein α-Subunit Gsα Is Required for Craniofacial Morphogenesis. PLoS ONE  9;11(2):e0147535. 

5)Ke Liu, Run Lei, Qiong Li, Xin-Xin Wang, Qian Wu, Peng An, Jianchao Zhang, Minyan Zhu, Zhiheng Xu, Yang Hong, Fudi Wang, Ying Shen, Hongchang Li,* & Huashun Li*. (2016) Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity.  Scientific Reports,16;6:21019.  

6)Ximing Shao, Ke Liu, Yi Fan, Zhihao Ding, Min Chen, Minyan Zhu, Lee S Weinstein, Hongchang Li*, Huashun Li*. (2015) Gαs Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize VE-cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity. Journal of genetics and Genomics, 42(11):613-624. 

7)Ke Liu, Quan Lin, Yanxia Wei, Renbing He, Ximing Shao, Zhihao Ding, Jianchao Zhang, Minyan Zhu, Lee S. Weinstein, Yang Hong, Hongchang Li *, Huashun Li*. (2015) Gas regulates asymmetric cell division of cortical progenitors by controlling Numb mediated Notch signaling suppression. Neuroscience Letters 597, 97–103  

8)Hongchang Li, Shawn Liu, Xiaoming Yang, Yun Wang, Bing Song, and Xiaoqi Liu. (2010) Plk1 phosphorylation of p150Glued facilitates nuclear envelope breakdown during prophase. Proc Natl Acad Sci USA. 107 (33), 14633-14638.  

9)Hongchang Li, Shawn Liu, Xiaoming Yang, Yingmin Wang, Yun Wang, Jerrold R. Turner, and Xiaoqi Liu. (2010) Phosphorylation of CLIP-170 by Plk1 and CK2 promotes timely formation of kinetochore-microtubule attachments. Embo J. 29, 2953-2965. 

10)Xiaoming Yang*, Hongchang Li*, X.Shawn Liu, Anping Deng, and Xiaoqi Liu. (2009) CDC2-mediated phosphorylation of CLIP-170 is essential for its inhibition of centrosome reduplication. J. Biol. Chem. 284, 28775-28782 (*, contributed equally)  

11)Hongchang Li, Yun Wang, and Xiaoqi Liu. (2008) Plk1-dependent phosphorylation regulates functions of DNA Topoisomerase IIa in cell cycle progression. J. Biol. Chem. 283, 6209-6221 



Tel: 0755-86585228; 18207554971