ZHANG Jian

Date:25-07-2017   |   【Print】 【close

Professor/Doctoral Supervisor 

  

Title

JIAN ZHANGPh.D

Professor/Doctoral Supervisor

Director of Center for Reproduction and Health Development

“Hundred Talents Program” of CAS,2011

Distinguished Younge Scholars of Shenzhen ,2012

Shenzhen overseas high-level talents (Peacock plan),2013

Member of American Diabetes Association, American Society for Endocrinology

Director of Reproductive Biology, branch of China Zoological Society

Areas of Interest

1. The role of polypeptides and their receptors in endocrine, metabolic and reproductive diseases, as well as their translation to clinic

Metabolic diseases include: obesity, fatty liver, diabetes, and osteoporosis.

Reproductive diseases include: infertility (premature ovarian failure, polycystic ovary syndrome, etc.), metabolic diseases of pregnancy (GDM, PE, obesity, etc.), endocrine-related tumors (endometrial cancer, ovarian cancer/breast cancer, etc.)

2. Application of biomaterials and biological imaging in reproductive diseases related to endocrine metabolism.

Education\Work experiences

1999-2003,Ph.D.in Physiology,Institute of Zoology, Chinese Academy of Sciences (Supervisor: Prof. Duan Enkui)

2003-2008,Postdoctoral Research in Stanford University(Supervisor: Prof. Aaron JW Hsueh)

2008-2010,Stanford University Research ScientistDec

2010 till now, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences

Papers\publications

Corresponding author or co- Corresponding author: SCI Articles 24

1     Huang B.#, Zhu W.#, Chang J.#, Dai X., Yu G., Huang C., Wang E., Li Z., Lin L., Wang B., Chen J., Xiao T., Niu J.*, Zhang J.*, The Role of G Protein-coupled Receptor 1 in Choriocarcinoma Progression[J], American journal of physiology, 2019(Accepted).

2.  Yao Z.#, Liu C.#, Yu X., Meng J., Teng B., Sun Y., Kerem G., Ismayi A., Fang P., Zhang J. V.*, Ren P.*, Microarray Profiling and Coexpression Network Analysis of Long Noncoding RNAs in Adipose Tissue of Obesity-T2DM Mouse[J], Obesity, 2019,27,1644-1651. doi:10.1002 /oby.22590.

3.  Sun L.#, Yang Y.#, Xiao T., Li M., Zhang J. V., Removal of DHT can relieve polycystic ovary but not metabolic abnormalities in DHT-induced hyperandrogenism mice [J]. Reproduction Fertility and Development, 2019, 31(10) 1597-1606.

4     Huang B., Huang C., Zhao H., Zhu W., Wang B., Wang H., Chen J., Xiao T., Niu J., Zhang J. V. The Impact of GPR1 Signaling on Maternal High-fat Feeding and Placenta Metabolism in Mice [J]. Am J Physiol Endocrinol Metab, 2019,316: E987-E997.

5     Zhao H., Yan D., Xiang L., Huang C., Li J., Yu X., Huang B., Wang B., Chen J., Xiao T., Ren P. G.,Zhang J. V. Chemokine-like receptor 1 deficiency leads to lower bone mass in male mice [J]. Cell Mol Life Sci, 2019, 76(2): 355-367.

6     Udduttula A., Li J., Zhao P., Wang G., Zhang J. V*., Ren P*. Sol-gel derived nanosized Sr-5(PO4)(2)SiO4 powder with enhanced in vitro osteogenesis and angiogenesis for bone regeneration applications [J]. Ceramics International, 2019, 45(3): 3148-3158.

7     Huang C., Huang B. B., Niu J. M., Yu Y., Qin X. Y., Yang Y. L., Xiao T. X., Chen J., Ren L. R.,Zhang J. V. Global mRNA and Long Non-Coding RNA Expression in the Placenta and White Adipose Tissue of Mice Fed a High-Fat Diet During Pregnancy [J]. Cellular Physiology and Biochemistry, 2018, 50(6): 2260-2271.

8          Zhang B., Tan L., Yu Y., Wang B., Chen Z., Han J., Li M., Chen J., Xiao T., Ambati B. K., Cai L., Yang Q., Nayak N. R., Zhang J.*, Fan X*. Placenta-specific drug delivery by trophoblast-targeted nanoparticles in mice [J]. Theranostics, 2018, 8(10): 2765-2781.

9          Yang Y. L., Sun L. F., Yu Y., Xiao T. X., Wang B. B., Ren P. G., Tang H. R., Zhang J.V. Deficiency of Gpr1 improves steroid hormone abnormality in hyperandrogenized mice [J]. Reproductive Biology and Endocrinology, 2018, 16: 1-11.

10    Jin P., Chen F. X., Li Y. Z., Zhang Q. Q., Zhang J. The clinical and experimental research on the treatment of endometriosis with thiostrepton [J]. Anticancer Agents Med Chem, 2018,doi: 10.2174/ 1871520618666180108100211.

11    Huang B. B., Liu X. C., Qin X. Y., Chen J., Ren P. G., Deng W. F., Zhang J. Effect of High-Fat Diet on Immature Female Mice and Messenger and Noncoding RNA Expression Profiling in Ovary and White Adipose Tissue [J]. Reprod Sci, 2018: 1933719118765966.

12    Li J., Xiang L., Jiang X., Teng B., Sun Y., Chen G., Chen J., Zhang J. V.*, Ren P. G. *Investigation of bioeffects of G protein-coupled receptor 1 on bone turnover in male mice [J]. J Orthop Translat, 2017, 10: 42-51.

13    Yang Y. L., Ren L. R., Sun L. F., Huang C., Xiao T. X., Wang B. B., Chen J., Zabel B. A., Ren P. G., Zhang J. V. The role of GPR1 signaling in mice corpus luteum [J]. Journal of Endocrinology, 2016, 230(1): 55-65.

14    Huang C., Wang M. M., Ren L. R., Xiang L., Chen J., Li M. X., Xiao T. X., Ren P. G., Xiong L. K., Zhang J. V. CMKLR1 deficiency influences glucose tolerance and thermogenesis in mice on high fat diet [J]. Biochemical and Biophysical Research Communications, 2016, 473(2): 435-441.

15      Li J., Xu Q., Teng B., Yu C., Li J., Song L., Lai Y. X., Zhang J., Zheng W.,Ren P. G. Investigation of angiogenesis in bioactive 3-dimensional poly (d,l-lactide-co-glycolide)/nano-hydroxyapatite scaffolds by in vivo multiphoton microscopy in murine calvarial critical bone defect [J]. Acta Biomater, 2016, 42: 389-399.

16      Tang M., Huang C., Wang Y. F., Ren P. G., Chen L., Xiao T. X., Wang B. B., Pan Y. F., Tsang B. K., Zabel B. A., Ma B. H., Zhao H. Y., Zhang J. V. CMKLR1 deficiency maintains ovarian steroid production in mice treated chronically with dihydrotestosterone [J]. Scientific Reports, 2016, 6.

17      Guo C. Z., Li J., She C., Shao X. Z., Teng B., Feng J., Zhang J. V.*, Ren P. G. *Bioeffects of micron-size magnesium particles on inflammatory cells and bone turnover in vivo and in vitro [J]. Journal of Biomedical Materials Research Part B-Applied Biomaterials, 2016, 104(5): 923-931.

18      Qiu C.*, Zhang J.*, Su M. P.,Fan X. J. Nuclear factor-kappa B mediates the phenotype switching of airway smooth muscle cells in a murine asthma model [J]. International Journal of Clinical and Experimental Pathology, 2015, 8(10): 12115-12128.

19      Zhang Q. Q., Fan X. J., Zhang J. The Role of Adipokine Chemerin in Pregnancy Complications [J]. Progress in Biochemistry and Biophysics, 2015, 42(10): 962-968.

20      Tian X. F., Ma W. J., Fang G.G., Xiao T. X., Chen J., Zhang J.. The Effects of Experimental Mice Adipose Accumulation by Targeting GPR1 Pathway. Progress in Biochemistry and Biophysics,2015,42(5):457-467.

21      Li L., Huang C., Zhang X., Wang J. B., Ma P., Liu Y. J., Xiao T. X., Zabel B. A., Zhang J. V. Chemerin-Derived Peptide C-20 Suppressed Gonadal Steroidogenesis [J]. American Journal of Reproductive Immunology, 2014, 71(3): 265-277.

22      Li L., Ma P., Huang C., Liu Y. J., Zhang Y., Gao C., Xiao T. X., Ren P. G., Zabel B. A., Zhang J. V. Expression of chemerin and its receptors in rat testes and its action on testosterone secretion [J]. Journal of Endocrinology, 2014, 220(2): 155-163.

23      Li L., Ma P., Liu Y. J., Huang C., O W. S., Tang F., Zhang J. V. Intermedin Attenuates LPS-induced Inflammation in the Rat Testis [J]. Plos One, 2013, 8(6).

24       Zhang J. V., Li L., Huang Q. S.,Ren P. G. Obestatin Receptor in Energy Homeostasis and Obesity Pathogenesis [J]. Prog Nucleic Acid Res Mol Biol, 2013, 114: 89-107.

 

First author or co-first author Articles14

1.      ng J. V., Jahr H., Luo C. W., Klein C., Van Kolen K., Donck L. V., De A., Baart E., Li J., Moechars D.,Hsueh A. J. W. Obestatin induction of early-response gene expression in gastrointestinal and adipose tissues and the mediatory role of G protein-coupled receptor, GPR39 [J]. Molecular Endocrinology, 2008, 22(6): 1464-1475.

2.      Samson W. K., Zhang J. V., Avsian-Kretchmer O., Cui K., Yosten G. L. C., Klein C., Lyu R. M., Wang Y. X., Chen X. Q., Yang J., Price C. J., Hoyda T. D., Ferguson A. V., Yuan X. B., Chang J. K.,Hsueh A. J. W. Neuronostatin Encoded by the Somatostatin Gene Regulates Neuronal, Cardiovascular, and Metabolic Functions [J]. Journal of Biological Chemistry, 2008, 283(46): 31949-31959.

3.      Zhang J. V., Klein C., Ren P. G., Kass S., Donck L. V., Moechars D.,Hsueh A. J. W. Response to comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake" [J]. Science, 2007, 315(5813).

4.      Zhang J. V., Ren P. G., Avsian-Kretchmer O., Luo C. W., Rauch R., Klein C.,Hsueh A. J. W. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake [J]. Science, 2005, 310(5750): 996-999.

5.      Li J., Zhang J. V., Cao Y. J., Zhou J. X., Liu W. M., Fan X. J.,Duan E. K. Inhibition of the beta-catenin signaling pathway in blastocyst and uterus during the window of implantation in mice [J]. Biology of Reproduction, 2005, 72(3): 700-706.

6.      Zhang J., Cao Y. J., Li F. Y., Li J., Yao L. B.,Duan E. K. Effects of fibronectin, VEGF and angiostatin on the expression of MMPs through different signaling pathways in the JEG-3 cells [J]. American Journal of Reproductive Immunology, 2003, 50(4): 273-285.

7.      Zhang J., Zhao Y. G., Cao Y. J., Sang Q. X. A.,Duan E. K. Expression and implications of tissue inhibitor of metalloproteinases-4 in mouse embryo [J]. Molecular Human Reproduction, 2003, 9(3): 143-149.

8.      Zhao Tianfu, Zhang Jian, Li Jing, Cao Yujing, Li Sumin, Zhou Jiaxi,Duan Enkui. Minimum effective dose and regulatory mechanism of angiostatin-inhibited embryo implantation in the mouse [J]. Acta zoologica Sinica, 2003, 49(3): 332-338.

9.      Zhao Tianfu, Zhang Jian, Li Jing, Cao Yujing, Li Sumin, Zhou Jiaxi, Li Fuyang, Yao Libo,Duan Enkui. Regulation effects of angiostatin on the mouse blastocysts [J]. Progress in Biochemistry and Biophysics, 2003, 30(5): 778-783.

10.  Zhang J., Cao Y. J., Zhao Y. G., Sang Q. X. A.,Duan E. K. Expression of matrix metalloproteinase-26 and tissue inhibitor of metalloproteinase-4 in human normal cytotrophoblast cells and a choriocarcinoma cell line, JEG-3 [J]. Molecular Human Reproduction, 2002, 8(7): 659-666.

11.  Li S. M., Cao Y. J., Zhang J., Tian Y. Q., Zheng X.,Duan E. K. Effects of vascular endothelial growth factor on MMPs during embryo implantation in mice [J]. Chinese Science Bulletin, 2002, 47(24): 2071-2074.

12.  Zhang J., Cao Y. J., Liu W. M., Zhao B. S., Zeng G. Q.,Duan E. K. Expression of matrix metalloproteinase-28 in human normal cytotrophoblast cells and a choriocarcinoma cell line, JEG-3 [J]. Chinese Science Bulletin, 2002, 47(9): 732-736.

13.  Zhang J., Tie G. D., Cao Y. J.,Duan E. K. Effect of fibronectin and leukaemia inhibitory factor on matrix metalloproteinases in mouse blastocyst [J]. Chinese Science Bulletin, 2001, 46(15): 1296-1300.

14.  Zhang J.,Duan E. K. Uteroglobin: Structure and function [J]. Progress in Biochemistry and Biophysics, 2001, 28(5): 627-630.

 

Co-author SCI Articles14

1.      o K.#*, Cheng G.#, Li D., Han J., Chen J., Wang B., Li M., Xiao T., Le A., Sun B., Jin Z., Zhang J., Fan X.*, Targeting delivery of partial VAR2CSA peptide guided N-2-Hydroxypropyl trimethyl ammonium chloride chitosan nanoparticles for multiple cancer types[J], Materials Science & Engineering C,2019(Accepted).

2.      Xiao Z. L., Li S. J., Yu Y., Li M. X., Chen J., Wang F., Zhang J., Deng W. F., Yang Q.,Fan X. J. VEGF-A regulates sFlt-1 production in trophoblasts through both Flt-1 and KDR receptors [J]. Molecular and Cellular Biochemistry, 2018, 449(1-2): 1-8.

3.      Zhang B. Z., Cheng G. G., Zheng M. B., Han J. Y., Wang B. B., Li M. X., Chen J., Xiao T. X., Zhang J., Cai L. T., Li S. J.,Fan X. J. Targeted delivery of doxorubicin by CSA-binding nanoparticles for choriocarcinoma treatment [J]. Drug Delivery, 2018, 25(1): 461-471.

4.      Wang L. W., Li J., Zhang J., He Q., Weng X. W., Huang Y. M., Guan M. J.,Qiu C. Inhibition of TRPC3 downregulates airway hyperresponsiveness, remodeling of OVA-sensitized mouse [J]. Biochemical and Biophysical Research Communications, 2017, 484(1): 209-217.

5.      Le A. W., Shan L. L., Dai X. Y., Xiao T. H., Li X. R., Wang Z. H., Zhang J., Chen X. Y. PI3K, AKT, and P-AKT levels in thin endometrium [J]. Genetics and Molecular Research, 2016, 15(1): gmr7184.

6.      Liu H. D., Xiong W., Liu Q. Y., Zhang J., Dong S. H. Chemokine-Like Receptor 1 Regulates the Proliferation and Migration of Vascular Smooth Muscle Cells [J]. Medical Science Monitor, 2016, 22: 4054-4061.

7.      Xiao Z. L., Yang Q., Zhang J., Fan X. J.. Advance of Animal Models for Preeclampsia. Progress in Biochemistry and Biophysics, 2016, 43(6):563-569 .

8.      Jia Q. Y., Cheng W. X., Yue Y., Hu Y. P., Zhang J., Pan X. H., Xu Z. W.,Zhang P. Cucurbitacin E inhibits TNF-alpha-induced inflammatory cytokine production in human synoviocyte MH7A cells via suppression of PI3K/Akt/NF-kappa B pathways [J]. International Immunopharmacology, 2015, 29(2): 884-890.

9.      Pandey V., Wu Z. S., Zhang M., Li R., Zhang J., Zhu T.,Lobie P. E. Trefoil factor 3 promotes metastatic seeding and predicts poor survival outcome of patients with mammary carcinoma [J]. Breast Cancer Research, 2014, 16(5).

10.  Graham K. L., Zhang J. V., Lewen S., Burke T. M., Dang T., Zoudilova M., Sobel R. A., Butcher E. C.,Zabel B. A. A Novel CMKLR1 Small Molecule Antagonist Suppresses CNS Autoimmune Inflammatory Disease [J]. Plos One, 2014, 9(12).

11.  Zhao L., Purandare B., Zhang J.,Hantash B. M. beta2-Microglobulin-free HLA-G activates natural killer cells by increasing cytotoxicity and proinflammatory cytokine production [J]. Hum Immunol, 2013, 74(4): 417-24.

12.  Mazerbourg S., Bouley D. M., Sudo S., Klein C. A., Zhang J. V., Kawamura K., Goodrich L. V., Rayburn H., Tessier-Lavigne M.,Hsueh A. J. Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality [J]. Molecular Endocrinology, 2004, 18(9): 2241-54.

13.  Cai L., Zhang J.,Duan E. Dynamic distribution of epidermal growth factor during mouse embryo peri-implantation [J]. Cytokine, 2003, 23(6): 170-8.

14.  Dai B. J., Cao Y. J., Wang X. C., Zhou J. X., Zhang J., Chen D. Y.,Duan E. K. Expression of LIF, VEGF, CD57 and CD68 after the transfer of rat embryos to mouse uteri [J]. Chinese Science Bulletin, 2003, 48(6): 542-548.

 

Chinese Core Journals or other publiciations(20)

1.    Li R.R., Li X., Ma B. H.*, Zhang J.*. Advances in adipsin research. Journal of Public Health and Preventive Medicine, 2019,30(2):74-78

2.    Yu G. Y., Dai X. Y., Zhang J., Li Q. X., Cao G. S., Jin P..Impact of CMKLR1 on migration and proliferation properties of endometrial carcinoma. Progress in Obstetrics and Gynecology, 2018,277:512-517

3.    Fan X.J, Huang C., Chen Z. L., Wang H.F., Huang B.B., Zhang J..Metabolic disorders during pregnancy and placenta development.Chinese Journal of Practical Gynecology and Obstetrics, 2018, 34(9):959-963

4.    Chen Z. L., Zhang J., Yang Q.* and Fan X. J.*, A Secreted Protein in the Wnt Signaling Pathway-R-Spondin3: A Mini-Review, Significances of Bioengineering & Biosciences, 2018 May 22.Volume 1-Issue-4.

5.    Huang B. B., Qin X. Y., Tang H. R., Jin P., Zhang J.. Longnon-coding NAs andits research progressin metabolic diseases. Journal of Public Health and Preventive Medicine, 2017, 28(2):80-84.

6.    Xue L.#, Yu Y.#, Zeng F. #,Tang H. R., Xiang L., Chen J., Xiao T. X., Ren P. G., Zhang J V.,. Alleviation of Diet-Induced Fat Accumulation by a Small Molecule CMKLR1 Antagonist in Mice. Journal of Steroids & Hormonal Science. 2018, Vol 9(1): 191 DOI: 10.4172/2157-7536.1000191.

7.    Sun L. F., Xue L.,Yang Y. L., Zhang J.. The Research Progress on Irisin and Energy Metabolism, Progress in Physiological Sciences,,2017,48(6):409-416.

8.    Sun L.F, Yang Y. L., Zhang J..Review on Progress in Chemerin, anAdipokine, and Polycystic OvarianSyndrome (PCOS). Journal of Integration Technology,2017 , 6 (6) :59-71.

9.    Liu H. D., Xiong W., Liu Q. Y., Li J. H., Wu M. S., Zhang J., Dong S. H.. Role of CMKLRl on mouse vascular smooth muscle cells proliferation and related mechanism. Chinese Journal of Cardiology, 2016, 44(7), 605-609.

10.Jiang X. T., Xiang L., Fan X. J., Ge L. J., Zhang J.. Effects of Chemokine-Like Receptor 1 Signal Pathway on Mice Inducedby Dihydrotestosterone Increased Bone Mineral Density, Journal of Integration Technology,2017,62:32-40.

11.Li J.#,Teng B.#, Lin R.Q., She C.,Yao Z. Y., Zhang J.,Song L.,Ren P. G.*. Neovasculature in 3D-PLGA/nHAp Scaffolds for Murine Critical sized Bone Defect Regeneration by Photoacoustic Imaging: A Preliminary Study[J]. International Advanced Research Journal in Science, Engineering and Technology,2016,DOI10.17148.

12.Liu H. D., Xiong W., Liu Q. Y., Li J. H., Wu M. S., Zhang J., Dong S. H.. Role   of CMKLR1 Receptor in the Proliferation of Mouse Vascular Smooth Muscle Cells. Journal of Medical Research, 2016 , 45 (4) :76-79.

13.Xiong W., Dong S. H.,Zhang J., Li J. H., Liao B. H., Pang X. L., Luo L. J.. The research of chemerin promoting proliferation of vascular smooth muscle cells , Journal of Clinical Cardiology,2016,321,66-69.

14.Xiong W., Dong S. H., Zhang J., Li J. H., Wu M. S., Liao B. H., Pang X. L., Luo L. J. Construction and identification of vascular smooth muscle cell lines from Chn1 gene deficient mice,Guangdong Medical Journal,2015,(16):2495-2498.

15.Xiong W., Dong S. H., Zhang J., Li J. H., Liao B. H.,Pang X. L., Luo L. J.. Chemerin promotes proliferation of mouse vascular smooth muscle cells by up-regulating p-JNK,Chinese Journal of Pathophysiology, 2015,(12): 2282-2286.

16.Sun L. F., Yang Y. L., Zhang J.. Oxidative stress induced by obesity and its effect on sexual reproduction. Journal of Public Health and Preventive Medicine,2015,26(4):71-73.

17.Tian X. F., Ma W. J., Zhang J.. The relationship between chemerin and nonalcoholic fatty liver disease. Journal of Public Health and Preventive Medicine, 2015, 26(2):75-77.

18.Chen Z., Xu Z. W., Xiang L., Zhang P., Zhang J.. The perspective of the relationship between chemerin and osteoporosis. Chinese Journal of Osteoporosis,2014,(12):1506-1510.

19.Huang Q. S., Xiao T. X., Zhang J., Wei Y.J. . Molecular Dynamics Simulation of Endothelin-1 Conformational Changes within Uniform Flow, Journal of Integration Technology, 2014,2(02):17-262014,3(2),17-26.

20.Zhang J., Duan E. K..Prospect of space reproductive, developmental biology and tissue engineering,Chinese Journal of Aerospace Medicine,2001,12(3):184-186.

 

Invited Oran Presentation and Posters(40)

1.        Chen Huang,Jian V. Zhang . The role of chemerin/CMKLR1 signaling on pregnancy mice and gestational diabetes mellitus. The second joint annual meeting of reproductive biology branch of Chinese society of zoology and the professional committee of reproductive science of Chinese society of physiology,Aug,2017China(corresponding author)

2.        Li-Feng SUN#, Ya-Li YANG#, Yan-YU, Tian-Xia XIAO, Meng-Xia LI, Hui-Ru TANG, Jian V. ZHANG*.Abnormal Gene Expression in Ovaries and Gonadal adipose tissue in a DHT-induced Polycystic Ovary Syndrome (PCOS) Mouse model, 1.The second joint annual meeting of reproductive biology branch of Chinese society of zoology and the professional committee of reproductive science of Chinese society of physiology,Aug,2017China(corresponding author)

3.        Ya-Li Yang#, Li-Feng Sun#, Yan Yu#, Tian-Xia Xiao, Bao-Bei Wang, Pei-Gen Ren, Hui-ru Tang, Jian V. Zhang. Deficiency of GPR1 improve steroid hormone abnormality in hyperandrogenism mice.The second joint annual meeting of reproductive biology branch of Chinese society of zoology and the professional committee of reproductive science of Chinese society of physiology,Aug,2017China(*corresponding author)

4.        Bin-bin Huang#, Xiao-Chun Liu#, Xiao-yun Qin, Jie Chen, Liang Xiang, Pei-gen Ren, Wei-fen Deng*, Jian Zhang*, Effect of High-fat Diet on Genome-wide Profiles in Ovary and White Adipose Tissue of Immature Female Mice, The second joint annual meeting of reproductive biology branch of Chinese society of zoology and the professional committee of reproductive science of Chinese society of physiology,Aug,2017China(corresponding author)

5.        Guo-gang Cheng , Ju-zuo Zhang ,Hua-shan Zhao , Bao-zhen Zhang ,Jin-yu Han , Jie Chen , Bao-bei Wang , Meng-xia Li , Tian-xia Xiao , Jian Zhang*, Xiu-jun Fan*, Rapid isolation of placenta extracellular vesicles via affinity chromatography. The second joint annual meeting of reproductive biology branch of Chinese society of zoology and the professional committee of reproductive science of Chinese society of physiology,Aug,2017China(corresponding author)

6.        Juzuo Zhang, Anwen Yuan, Xuan Peng, Zhilong Chen, Xiujun Fan, Jian V Zhang,Qing Yang*, Liqun Xue*. Peroxisome proliferator-activated receptor gamma (PPARγ) mediates porcineangiogenesis through VEGF signals. The second joint annual meeting of reproductive biology branch of Chinese society of zoology and the professional committee of reproductive science of Chinese society of physiology,Aug,2017China(corresponding author)

7.        Lunbo Tan #,Yan Yu#, Zhi-long Chen,Fen SunBao-zhen Zhang,Tian-xia Xiao,Jian.v.Zhang*Qing Yang*Xiu-jun Fan*, The role and mechanism of overexpression of chemerin in mouse placenta, The second joint annual meeting of reproductive biology branch of Chinese society of zoology and the professional committee of reproductive science of Chinese society of physiology,Aug,2017China(corresponding author)

8.        YaliYang,LifengSun,Jian Zhang.The role of GPR1 signaling in mice corpus luteum.The 4th SKLRB Symposium on Reproductive Biology,Oct,2016China(corresponding author)

9.        LifengSun,Yali Yang,Jian Zhang .Abnormal genes’ expression in ovaries and gonadal white adipose tissue in DHT induced polycystic ovary syndrome  (PCOS) mice model.The 4th SKLRB Symposium on Reproductive BiologyOct,2016China(corresponding author)

10.    Xiao-yunQin,Pei-Gen Ren*, Jian V. Zhang.Chemerin secreted from gonadal adipose tissue promotes ovarian cancer progression through the CMKLR1 signaling pathway.The 4th SKLRB Symposium on Reproductive BiologyOct,2016China(corresponding author)

11.    LunboTan,Jian V Zhang*,Xiujun Fan*.The Role of Chemerin in Trophoblast Invasion and Potential Implication in the Disease Development of Preeclampsia.The 4th SKLRB Symposium on Reproductive BiologyOct,2016China(corresponding author)

12.    Chen huang,Binbinhuang,Jian.V.zhang.The role of chemerin/CMKLR1 signaling on gestational diabetes mellitus and fetus.The 4th SKLRB Symposium on Reproductive BiologyOct,2016China(corresponding author)

13.    BinbinHuang,XiaoyunQin,Jian V Zhang.Effects of High-Fat Diet on The Reproductive System of Immature Female Mice.The 4th SKLRB Symposium on Reproductive BiologyOct,2016China(corresponding author)

14.    BinbinHuang,Jian V Zhang.The Effect of GPR1 Signaling on The Pathogenesis of Gestational Diabetes Mellitus in HFD-induced Maternal Mice.The 4th SKLRB Symposium on Reproductive BiologyOct,2016China(corresponding author)

15.    LiangXiang,JianV.Zhang.The effect of CMKLR1 signaling on white and brown adipose tissue adiposity induced by androgen. The 4th SKLRB Symposium on Reproductive BiologyOct,2016China(corresponding author)

16.    Liang Xiang,Jian V. Zhang.CMKLR1 Deficiency Leads to Testosterone-induced Bone Loss through the Regulation of Osteoblast and Osteoclast Formation.The 4th SKLRB Symposium on Reproductive BiologyOct,2016China(corresponding author)

17.    Liang Xiang, Lanxiang Li,Chen Huang, Tianxia Xiao,Jian V.Zhang.Deficiency of CMKLR1 leads to bone loss through reducing testosterone synthesis by leydig cells in mice. Current Topics in Reproductive Biology,A-18,Oct,2015(China) (corresponding author)

18.    Chen Huang, Mi Tang, Miaomiao Wang, Yanfei Pan, Jie Chen, Mengxia Li, Tianxia Xiao, Jian Zhang.CMKLR1 may influence Glucose Metabolism through white to brown fat switch. Current Topics in Reproductive Biology ,A-116, Oct,2015(China)(corresponding author)

19.    Ya-Li Yang, Chen Huang, Li-Feng Sun, Tianxia Txiao,Bao-Bei Wang, Jie Chen,Jian V.Zhang, The Role of Chemein/GPR1 Signaling in Corpus Luteum Development in Mice, Current Topics in Reproductive Biology,S1-S26,Oct , 2015(China) (corresponding author)

20.    Mi Tanga, Chen Huang, Yu-Fei Wang, Pei-Gen Ren, Tian-Xia Xiao, Bao-Bei Wang, Yan-Fei Pan, Benjamin K. Tsange, Brian A Zabel, Bao-Hua Ma, Hui-Ying Zhaoa*, Jian V. Zhang.CMKLR1 deficiency protects against experimental dihydrotestosterone -induced polycystic ovary syndrome. Ovarian Club V, 2015January 31(HONGKONG)(*corresponding author)

21.    Jian V Zhang. Preliminary research of CMKLR1 signaling system in several metabolic diseases. Symposium on China Zoological Society Seventeenth National Congress, November 17-20,Guangzhou,China(*corresponding author)

22.    Qingqing Zhang,Zhonglin Xiao,Tianxia Xiao, Jie Chen, Yanfei Pan, Xiujun Fan,Jian Zhang.Effects of CMKLR1 deficiency on the number of peripheral blood lymphocytes during early pregnancy in mice. Third SKLRB Symposium on Reproductive Biology October 26-30, 2014,China(corresponding author)

23.    Lei Li, Ping Ma, Chen Huang,Jian V Zhang. Expression and Suppressive Effect of Novel Adipokine Chemerin on Rodent GonadalSteroidogenesis. China Zoological Society of Reproductive Biology Branch Fourteenth Symposium, 2013, China (corresponding author)

24.    Ping Ma, Lei Li, Chen Huang,Tian-Xia Xiao, Jian V Zhang.Peri-implantation antagonism of chemerin/CMKLR1 signal compromises fetoplacental development. China Zoological Society of Reproductive Biology Branch Fourteenth Symposium, 2013, China (corresponding author)

25.    Chen Huang,YU-Fei Wang,Tian-Xia Xiao, Jian V Zhang ,Effect of CMKLR1 deficiency on DHT-induced PCOS in mice. China Zoological Society of Reproductive Biology Branch Fourteenth Symposium, 2013, China (corresponding author)

26.    Xu ZHANG, Qin-ce SUN, Shu-Hua Mu, Yong-jun LIU, Ping Ma, Wen-juan XU, Jian V. ZHANG.Effect of novel cmklr1 small molecule antagonist on steatosis and inflammation of nonalcoholic fatty liver disease in mice. ENDO 2013: The 95th Annual Meeting & Expo, San Francisco, California. USA(corresponding author)

27.    Qin-ce SUN,1Shu-hua MU, Xu ZHANG, Yong-jun LIU, Ping MA, Wen-juan XU, Jian V Zhang. Novel cmklr1 small molecule antagonist regulates adipogenesis and obesity. ENDO 2013: The 95th Annual Meeting & Expo, San Francisco, California. USA (*corresponding author)

28.    ChunHong Yu, Jian Zhang. Cathepsin C Cleaves Mouse Chemerin To Novel Derived Peptide mC-20, With Potent Activity Toward CMKLR1. 7th International Huaxia Congress of Endocrinology. 2012. HongKong. (corresponding author)

29.    Lei Li, Jian Zhang. Suppression of gonadal steroidogenesis by novel adipokine chemerin: A bridge between obesity and fertility. 7th International Huaxia Congress of Endocrinology. 2012. HongKong. (corresponding author)

30.    Qingsheng Huang, Tianxia Xiao, Jian V. Zhang, “Computational modeling of full-length prochemerin from human,” Proceedings of the IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI 2012), pp. 755-758. (IEEE-EMBS International Conference on Biomedical and Health Informatics, Hong Kong and Shenzhen, China, 2-7 Jan 2012)(corresponding author)

31.    Lewen S, Zhang, J, Zabel BA, Role of the Chemerin Receptor CCRL2 in Peanut-induced Anaphylaxis, Annual FOCIS Meeting, Vancouver, BC, Canada June 2012.

32.    Zabel BA, Zhang J, Lewen S, Burke TM, Zoudilova M, Sobel RA, Butcher EC, Graham KL, Novel CMKLR1 Small Molecule Antagonist Suppresses Autoimmune Demyelinating Disease, Annual FOCIS Meeting, Vancouver, BC, Canada June 2012.

33.    Huang QS, Xiao TX, Zhang JV. Computational modeling of full-length prochemerin from human.  IEEE-EMBS International Conference on Biomedical and Health Informatics, 2012, Shenzhen. p98.(corresponding author)

34.    LI Lei, O Wai-sum, MA Ping, TANG Fai, ZHANG JV. The expression of arenomedullin2 in the rat male reproductive system. Current Topics in Reproductive Biology. 2011.Nov;p60-60.(corresponding author)

35.    Hsueh AJ, Zhang JV, . Bioinformatic approaches to the discovery of novelpeptide hormones. University College Dublin (2009) Proc Physiol Soc 15, SA44.

36.    Zhang JV, Hsueh AJW. Obestatin induction of early response gene expression in gastrointestinal and adipose tissues and the mediatory role of GPR39. 90th Endocrine Meeting, San Francisco, CA 2008 poster presentation.

37.    Zhang JV, Ren PG, et al. Ovarian expression of obestatin and its receptor, GPR39. 10th Annual Reproductive Research Day. 2006 poster presentation.

38.    Zhang JV, Kretchmer OA, Luo CW, et al. Identification of a novel peptide cospeptin and its role in ovarian paracrine regulation. 9th Annual Reproductive Research Day. 2005 poster presentation.

39.    Zhang J, Duan EK. Effects of fibronectin, VEGF and angiostatin on the expression of MMPs through different signaling pathways in the JEG-3 cells. 8th AASIR in Weimar, Germany. 2002 poster and oral presentation.

Zhang J, Duan EK. Expression of matrix metalloproteinase-26 and tissue inhibitor of metalloproteinase-4 in human normal cytotrophoblast cells and a choriocarcinoma cell line, JEG-3. 8th Reproductive Biology Meeting, Zhangjiajie,Hunan, China 2001 oral presentation.