ZHAO, Xiaoli  (Ph.D, Ms) 

Phone：

86-755-86585233

15017600478

Fax: 85-755-86585222  

Email：zhao.xl@siat.ac.cn  

Institute of Biomedicine and Biotechnology,Shenzhen institutes of Advanced Technology, Chinese Academy of Science 

Zhao, Xiaoli, Associate professor, Ph.D, supervisor of postgraduate. Graduated from The University of HongKong, visiting scholar in Johns Hopkins University，vice director of Shenzhen Key Laboratory of Marine Biomedical Materials，Shenzhen Overseas High-Caliber Personnel.Research interest in biomaterials, drug delivery, stem cell and tissue regeneration.

Published more than 20 SCI paper in JBMR, Acta Biomaterialia and so on. Report in national and international conference, got the young investigator travel grant in ASBMR. 

Education and Work experience                                                                

●2014,1-now    

Associate Professor  Institute of Biomedicine and Biotechnology, Shenzhen Chinese Academy of Science 

●2012,1-2013.12 

Assistant Profector  Institute of Biomedicine and Biotechnology, Shenzhen Chinese Academy of Science 

●2011,8-2011,12   Research assistant, Dept of Orthopaedic and Traumatology, The University of Hong Kong. 

●2007,9-2011,8    Ph.D. in Orthopaedic Biomaterials  Dept of Orthopaedic and Traumatology, The University of Hong Kong. 

●2010,11-2011,5   Exchange scholar in Bone Biology, Dept of Orthopaedic Surgery,  Johns Hopkins University,  USA. 

●2001,9-2007,7    Master and Bachelor in Biomaterials, Tianjin University,  

Rasearch Interests                                                                   

Bone Regeneration: Using scaffold, hydrogel, drug release and gene delivery for bone regeneration. 

Biomaterials: Intelligent biomaterials with response to temperature and pH, targeted drug and gene delivery, injectable hydrogel or bone cement. 

Stem cell: Biomaterials regulated stem cell migration, differentiation, and their interaction.      

Publications:                                                                            

1.         Chen qingchang, Liu Yuan, Wang Ting, Wu Jun, Zhai Xinyun, Li Yanqun, Lu W William, Pan Haobo, Zhao Xiaoli*. Chitosan-PVA monodisperse millimeter-sized spheres 1 prepared by electrospraying reduce the thromboembolic risk in hemorrhage. Journal of Materials Chemistry B, 2017, 2017,5, 3686-3696 

2.         Zhao Y, Wong HM, Lui SC, Chong EYW, Wu GS, Zhao XL, et al. Plasma Surface Functionalized Polyetheretherketone for Enhanced Osseo-Integration at Bone-Implant Interface. Acs Appl Mater Inter. 2016;8:3901-11. 

3.         Wenlong Liu, Ting Wang, Xiaoli Zhao, Xiuli Dan, William W. Lu, Haobo Pan. Akermanite used as an alkaline biodegradable implants for the treatment of osteoporotic bone defect. Bioactive Materials, 2016,1,151-9 

4.         Zheng CP, Pan HB, Zhao Xiaoli*.  Alendronate-modified liposome for bone targeting gene delivery regulating mesenchymal stem cell migration. Journal of Orthopaedic Translation, 2016,7,128 

5.         Chen QC, Pan HB, Zhao Xiaoli*. Chitosan/PVA/Bioglass multilayer films for wound dressing application. Journal of Orthopaedic Translation, 2016,7,117-118 

6.         Li YQ, Pan HB, Zhao Xiaoli*. Promoting effect of strontium on the division of stem cells in bone formation. Journal of Orthopaedic Translation, 2016,7,129 

7.         Wu Jun#, Zhao Xiaoli#, Yeung KW, To MK. Interfacial Fast Release Layer in Monodisperse Poly (lactic-co-glycolic acid) Microspheres Accelerates the Drug Release. Current Drug Delivery,2016,13(5):720-9（IF：1.478, SCI 3区） 

8.         Wu S, Wu J, Yue JH, To MKT, Pan HB, Lu WW, Zhao XL*, Poly(d,l-lacticacid) electrospun fibers with tunable surface nanotopography for modulating drug release profiles. Materials Letters,2015,161:716-19. （IF：2.489, SCI 1区） 

9.         Wu S, Huang ZY, Yue JH, Liu D, Wang T, Ezanno P, Ruan CS, Zhao XL*, Lu WW, Pan HB. The efficient hemostatic effect of Antarctic krill chitosan is related toits hydration property. Carbohydrate Polymers, 2015,132:295-303. （IF：4.074, SCI 1区） 

10.     Yue JH, Wu J, Liu D, Zhao XL*, Lu WW. BMP2 gene delivery to bone mesenchymal stem cell by chitosan-g-PEI nonviral vector. Nanoscale Research Letters,2015,10:203.（IF：2.779，SCI 2区） 

11.     Wang L, Zhang L, Pan H, Peng S, Zhao X, Lu WW. Abnormal subchondral bone microstructure following steroid administration is involved in the early pathogenesis of steroid-induced osteonecrosis. Osteoporosis International, 2016;27:153-9.（IF：4.169, SCI 2区） 

12.     Zhao XL，Li ZY, Pan HB, Liu WG, Lv MM, Leung F, Lu WW. Enhanced gene delivery by chitosan-disulfide-conjugated LMW-PEI for facilitating osteogenic differentiation. Acta Biomater, 2013, 9(5):6694-6703. (IF:5.091) 

13.     Zhao XL, Li ZY, Liu WG, Lam WM, Sun P, Kao RYT, Luk KDK, Lu WW. Octaarginine-modified chitosan as a nonviral gene delivery vector: properties and in vitro transfection efficiency. J nanopart res, 2011,13:693-702. (IF:2.175) 

14.     Zhang JL, Wang N, Liu WG, Zhao XL, Lu William. Intermolecular hydrogen bonding strategy to fabricate mechanically strong hydrogels with high elasticity and fatigue resistance. Soft Matter, 2013,9:6331-6337. (IF:3.909) 

15.     Zhao XL, Yu B, Xian LL, Lu W, Wan M, Cao X. Nestin as marker for bone marrow mesenchymal stem cells. J Bone Miner Res, 2011, S2, 1006 

16.     Yu B, Zhao XL, Yang CZ, Crane J, Xian LL, Lu WW, Wan M, Cao X. PTH Induces Differentiation of Mesenchymal Stem Cells by Enhancing BMP Signaling. J Bone Miner Res, 2012,29,2001-2014. (IF:6.128) 

17.     Zhao XL, Liu WG, Chen DY, Lin XZ, Lu WW. Effect of block order of ABA- and BAB-type NIPAAm/HEMA triblock copolymers on thermoresponsive behavior of solutions. Macromol Chem Phys, 2007, 208,1773-1781. (IF:2.386) 

18.     Pan HB, Zhao XL, Darvell WB, Lu WW. Apatite-formation ability – predictor of “bioactivity”? Acta Biomaterialia, 2010,6， 4181-4188.(IF:5.039) 

19.     Pan HB, Zhao XL, Zhang X, Zhang KB, Li LC, Li ZY, Lam WM, Lu WW, Wang DP, Huang WH, Lin KL, Chang J. Strontium borate glass: potential biomaterial for bone regeneration. J R Soc Interface, 2010, 7,1025-1031.(IF:4.097) 

20.     Bai T, Zhang P, Han YJ, Liu YA, Liu WG, Zhao XL, Lu WW. Construction of an ultrahigh strength hydrogel with excellent fatigue resistance based on strong dipole-dipole interaction. Soft Matter, 2011,7(6):2825-2831.(IF:4.457) 

21.     Dai FY, Tang L, Yang JH, Zhao XL, Liu WG，Chen G, Xiao FS, Feng XQ. Fast thermoresponsive BAB-type HEMA/NIPAAm triblock copolymer solutions for embolization of abnormal blood vessels. J Mater Sci Mater Med, 2009, 20, 967-974.(IF:2.325) 

22.     Cao ZQ, Liu WG, Ye GX, Zhao XL, Lin XZ, Gao P, Yao KD. N-isopropylacrylamide/2-Hydroxyethyl Methacrylate Star Diblock Copolymers: Synthesis and Thermo-responsive Behavior. Macromol Chem Phys, 2006, 207, 2329-2335. (IF:2.386) 

23.     Tian F, Zhang BQ, Zhao XL*, Ji WH, Li XW, Cheng GX, Yao KD. In vitro evaluation of embolization effects of thermosensitive N-isopropylacrylamide based copolymer solutions.   Polymer International, 2006, 55, 405-408. (IF:2.125, corresponding author) 

Conferences report:                                                                    

1.       2016 The 11th International Congress of Chinese Orthopaedic Association. Strontium promotes the asymmetric difision of MSC during the osteogenic differentiation.  

2.       2016 HKU International Symposium for 3D Bio-printing and Biomaterials, Alkaline biodegradable implants for osteoporotic bone defects-importance. 

3.       2016 International Combined Meeting of Orthopaedic Research Societies (2016-ICORS), Alendronate-modified liposome for bone targeting gene delivery regulating mesenchymal stem cell migration. 

4.       2016 The 26th Interdisciplinary Research Conference on Injectable Osteoarticular Biomaterials and Bone Augmentation Procedures (GRIBOI), Alendronate-modified liposome for bone targeting gene delivery.  

5.       2015 Chinese Biomaterials Congress, Functional Selenium Nanoparticles Enhanced Stem Cell Osteoblastic Differentiation through BMP Signaling Pathways. 

6.       21st Annual conference of ANZORS (Australian & New Zealand Orthopaedic Research Society), Strontium promotes the asymmetric division of MSC during the osteogenic differentiation.  

7.       China-Europe symposium on Biomaterials in Regenerative Medicine, Using high strength hydrogel to repair the cartilage in the loading area.  

8.       7th International conference on osteoporosis and bone research, xiamen，china， Strontium promote the osteogenic differentiation of MSC through attenuating the cell quiescent and enhancing asymmetric differentiation 

9.       20th Annual conference of Australian & New Zealand Orthopaedic Research Society, Strontium promote the osteogenic differentiation of MSC through attenuating the cell quiensent and enhancing asymmetric differentiation. 

10.  9th world biomaterials congress，Bioreducible Chitosan-ss-PEI as novel gene carrier for BMP2 gene deliveryZ 

11.   33rd Annual meeting of the American Society for Bone and Mineral Research, Nestin as a Marker for Bone Marrow Mesenchymal Stem Cells 

Patent                                                                           

1.      CN201610512519.7, 2016.07.04. 

2.      CN 201610515073.3, 2016.07.04. 

3.      PCT/CN2016/087283, 2016.06.27. 

4.      CN 201610339273.8, 2016.05.23. 

5.      CN 201610225339.0, 2016.04.13. 

6.      CN201610857216.9, 2016.09.28. 

7.      CN 103030813 B, 2015.08.05. 

8.      CN103665191B, 2016.01.20. 

9.      CN103736135B, 2015.11.04. 

10.   CN103705968B, 2015.10.28