GUAN Min
Date：29-07-2017 | 【Print】 【close】
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Research Center |
Research Interests | ||||
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GUAN Min |
Associate Research Professor |
Center for Human Tissues & Organs Degeneration |
Using cellular systems, pharmacological approaches and animal genetics to study the hormonal and pathophysiological regulations contributing to metabolic diseases such as osteoporosis, fatty liver, diabetes and obesity. | ||||
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Education | |||||||
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Present and Past Positions | |||||||
| Associate Professor Jan 2013 – Present Shenzhen Institutes of Advanced Technology, CAS, China Postdoctoral Fellow Advisor: Prof. Xu Cao Dec 2011 – Dec 2012 Johns Hopkins University, School of Medicine, MD, USA Postdoctoral Fellow Advisors: Prof. Wei Yao and Nancy E. Lane Nov 2009- Nov 2011 University of California, Davis Medical Center, CA, USA Ph.D. Graduate Student Advisor: Prof. Lin Chen Sep 2006 – July 2009 Guangzhou Institute of Biomedicine and Health, CAS, China Research Assistant Jul 2004-Aug 2006 Guangzhou Institute of Biomedicine and Health, CAS, China M.S. Graduate Student Advisor: Prof. Dongsheng Yao Sep 2001 - July 2004 Jinan University, China B.S., Undergraduate Student Sep 1997 - July 2001 Normal University of South China | |||||||
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Representative Publications | |||||||
| (1) Tongling Huang, Renzhong Liu, Xuekun Fu, Dongsheng Yao, Yang Lei, Meng Yang, Qingli Liu, William W. Lu, Chuanyue Wu, Min Guan*. Aging reduces an ERRα-directed mitochondrial glutaminase expression suppressing glutamine anaplerosis and osteogenic capacity of mesenchymal stem cells. Stem cells. 2017 Feb;35(2):411-424. (2) Qingli Liu, Meng Yang, Renzhong Liu, Yang Lei, Xuekun Fu, Caijun Sun, Haobo Pan, Chi-Wai Wong, Min Guan*. Activation of farnesoid X receptor promotes triglycerides lowering by inhibiting Phospholipase A2 G12B in hyperlipidemic mice. Molecular and Cellular Endocrinology 2016 Nov 15;436:93-101. (3) Zhao, Yuetao; Tong, Liping; Li, Yong; Pan, Haobo; Zhang, Wei; Guan, Min; Li, Weihao; Chen, Yixin; Li, Qing; Li, Zhongjun; Wang, Huaiyu*; Yu, Xuefeng*; Chu, Paul*. Lactose-Functionalized Gold Nanorods for Sensitive and Rapid Serological Diagnosis of Cancer. ACS Applied Materials & Interfaces. 2016 Mar 9;8(9):5813-20. (4) Yan Chen, Ting Wang, Min Guan, FKL Leung, Cao Xu, Wang Ting, Weiwei Zhao, Xiaohua Pan, and W W Lu*. Bone turnover and articular cartilage differences localized to subchondral cysts in knees with advanced osteoarthritis. Osteoarthritis and Cartilage. 2015 Dec;23(12):2174-83. (5) Yao W*#, Min Guan#, Jia JJ, Dai WW, Lay YE, Amugongo S, Liu RW, Olivos D, Lam KS, Nolta J, Olvera D, Ritchie RO, Lane NE. Reversing bone loss by directing mesenchymal stem cell to the bone. Stem cells 2013 Sep;31(9):2003-2014. # co-first author (6) Min Guan, Wei Yao*, Ruiwu Liu, Kit S Lam, Jan Nolta, Junjing Jia,Brian Panganiban, Liping Meng, Ping Zhou, Mohammad Shahnazari, Robert O Ritchie & Nancy E Lane. Directing mesenchymal stem cells to bone to increase bone formation. Nature Medicine. 2012 Feb 5; 18(3):456-62. (7) Min Guan, Linbing Qu, Wenjuan Tan, Ling Chen*, ChiWai Wong*. Hepatocyte nuclear factor-4 alpha regulates liver triglyceride metabolism in part through secreted phospholipase A2 GXIIB. Hepatology. 2011 Feb; 53(2):458-66. (8) Zhendong Zhong, Cassandra R. Zylstra-Diegel, Cassie A. Schumacher, Jacob J. Baker, April C. Carpenter, Sujata Rao, Wei Yao, Min Guan, Jill A. Helms, Nancy E. Lane, Richard A. Lang, Bart O. Williams*. Wntless functions in mature osteoblasts to regulate bone mass. Proc Natl Acad Sci USA. 2012 Aug 14;109 (33):E2197-204. (9) Junjing Jia, Wei Yao, Min Guan, Weiwei Dai, Mohammad Shahnazari, Rekha Kar, Lynda Bonewald, Jean X. Jiang and Nancy E. Lane*. Glucocorticoid Dose Determines Osteocyte Cell Fate. FASEB J. 2011 Oct;25(10):3366-76. 1) Tongling Huang, Renzhong Liu, Xuekun Fu, Dongsheng Yao, Yang Lei, Meng Yang, Qingli Liu, William W. Lu, Chuanyue Wu, Min Guan*. Aging reduces an ERRα-directed mitochondrial glutaminase expression suppressing glutamine anaplerosis and osteogenic capacity of mesenchymal stem cells. Stem cells. 2017 Feb;35(2):411-424. (2) Qingli Liu, Meng Yang, Renzhong Liu, Yang Lei, Xuekun Fu, Caijun Sun, Haobo Pan, Chi-Wai Wong, Min Guan*. Activation of farnesoid X receptor promotes triglycerides lowering by inhibiting Phospholipase A2 G12B in hyperlipidemic mice. Molecular and Cellular Endocrinology 2016 Nov 15;436:93-101. (3) Zhao, Yuetao; Tong, Liping; Li, Yong; Pan, Haobo; Zhang, Wei; Guan, Min; Li, Weihao; Chen, Yixin; Li, Qing; Li, Zhongjun; Wang, Huaiyu*; Yu, Xuefeng*; Chu, Paul*. Lactose-Functionalized Gold Nanorods for Sensitive and Rapid Serological Diagnosis of Cancer. ACS Applied Materials & Interfaces. 2016 Mar 9;8(9):5813-20. (4) Yan Chen, Ting Wang, Min Guan, FKL Leung, Cao Xu, Wang Ting, Weiwei Zhao, Xiaohua Pan, and W W Lu*. Bone turnover and articular cartilage differences localized to subchondral cysts in knees with advanced osteoarthritis. Osteoarthritis and Cartilage. 2015 Dec;23(12):2174-83. (5) Yao W*#, Min Guan#, Jia JJ, Dai WW, Lay YE, Amugongo S, Liu RW, Olivos D, Lam KS, Nolta J, Olvera D, Ritchie RO, Lane NE. Reversing bone loss by directing mesenchymal stem cell to the bone. Stem cells 2013 Sep;31(9):2003-2014. # co-first author (6) Min Guan, Wei Yao*, Ruiwu Liu, Kit S Lam, Jan Nolta, Junjing Jia,Brian Panganiban, Liping Meng, Ping Zhou, Mohammad Shahnazari, Robert O Ritchie & Nancy E Lane. Directing mesenchymal stem cells to bone to increase bone formation. Nature Medicine. 2012 Feb 5; 18(3):456-62. (7) Min Guan, Linbing Qu, Wenjuan Tan, Ling Chen*, ChiWai Wong*. Hepatocyte nuclear factor-4 alpha regulates liver triglyceride metabolism in part through secreted phospholipase A2 GXIIB. Hepatology. 2011 Feb; 53(2):458-66. (8) Zhendong Zhong, Cassandra R. Zylstra-Diegel, Cassie A. Schumacher, Jacob J. Baker, April C. Carpenter, Sujata Rao, Wei Yao, Min Guan, Jill A. Helms, Nancy E. Lane, Richard A. Lang, Bart O. Williams*. Wntless functions in mature osteoblasts to regulate bone mass. Proc Natl Acad Sci USA. 2012 Aug 14;109 (33):E2197-204. (9) Junjing Jia, Wei Yao, Min Guan, Weiwei Dai, Mohammad Shahnazari, Rekha Kar, Lynda Bonewald, Jean X. Jiang and Nancy E. Lane*. Glucocorticoid Dose Determines Osteocyte Cell Fate. FASEB J. 2011 Oct;25(10):3366-76. | |||||||
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Intelligent property | |||||||
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| Phone | 0755-86585232（office） | ||||||
| min.guan@siat.ac.cn | |||||||
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