2017.01 - Present Shenzhen Institutes of Advanced Technology, CAS, Professor
2012.02 - 2016.12 Stanford University School of Medicine, Postdoctoral Fellow
2008.09 - 2012.01 Havard Medical School, Massachusetts General Hospital, Visiting PhD student
2007.09 - 2012.01 The University of Hong Kong, Ph.D in Metabolic Syndrome and Diabetes
2005.09 - 2007.07 Tsinghua University, M.S. in Cell Biology
2001.09 - 2005.07 Tsinghua University, B.S. in Biological Sciences and Biotechnology
My group is interested in studying the cellular and molecular mechanisms controlling the central nervous system angiogenesis and blood-brain barrier, and develop new therapeutics for brain vascular diseases including ischemic stroke and glioblastoma.
1. Chang JL*, Mancuso MR*, Maier C, Liang XB, et al. Gpr124 is essential for blood-brain barrier integrity in central nervous system disease. Nature Medicine, Apr; 23(4): 450-460 (2017). Article. (*co-first author).
2. Furman D, Chang JL, Lartigue L, et al. Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. Nature Medicine, Jan; 23(2): 174-184 (2017). Article.
3. Hong GS*, Diao S*, Chang JL*, Antaris AL, et al. Through skull fluorescence imaging of the brain in a new near-infrared window. Nature Photonics, Aug; 8: 723-730 (2014). (*co-first author).
4. Yan KS, Janda CY, Chang JL, Zheng GX, et al. Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal. Nature, May; 545: 238-242 (2017).
5. Janda CY, Dang LT, You CJ, Chang JL, de Lau W, et al. Surrogate Wnt agonists that phenocopy canonical Wnt and b-catenin signaling. Nature, May; 545: 234-237 (2017).
6. Tsai HH, Niu JQ, Munji R, Davalos D, Chang JL, Zhang HJ, et al. Oligodendrocyte precursors migrate along vasculature in the developing nervous system. Science, Jan; 351(6271): 379-84 (2016).
7. Vallon M*, Chang JL*, Zhang HJ and Kuo CJ. Developmental and pathological angiogenesis in the central nervous system. Cellular and Molecular Life Sciences, Apr; 71:3489-3506 (2014). (*co-first author). ***Cover article.
8. Chang JL, Li YM, Huang Y, Lam KSL, Hoo RLC, Wong WT, Cheng KKY, Wang YQ, Vanhoutte PM and Xu AM. Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4A signaling pathway. Diabetes, Nov; 59(11): 2949-59 (2010).
2017-2019, CAS Pioneer Hundred Talents Program;
2015-2016, American Heart Association Postdoctoral Fellowship;
2008, Travel Grants for Exchange Activities of Research Students, The University of Hong Kong;
2007-2011, University Postgraduate Fellowship, The University of Hong Kong.