YANG Xiaolu

Date:29-07-2017   |   【Print】 【close

Experience 

Education: 

  

1985 

  

B.Sc. 

  

Tsinghua University, Beijing, China (Physical Chemistry) 

  

1992 

  

M.Phil. 

  

Columbia University, New York, NY (Genetics & Development) 

  

1994 

  

Ph.D. 

  

Columbia University, New York, NY (Genetics & Development) 

Faculty Appointments: 

  

1998-2002 

  

Assistant Professor of Molecular and Cellular Engineering, University of Pennsylvania School of Medicine  

  

2002-2005 

  

Assistant Professor of Cancer Biology, University of Pennsylvania School of Medicine  

  

2005-2011 

  

Associate Professor of Cancer Biology, University of Pennsylvania School of Medicine  

  

2011-present 

  

Professor of Cancer Biology, University of Pennsylvania School of Medicine  

  

Research Interests 

(1) 肿瘤细胞信号传导; 

 Tumor cell signal transduction;  

(2)细胞凋亡; 

 Cell apoptosis;  

(3)代谢调控; 

Metabolic regulation and control; 

  

Representative Publications 

  

  

1. Yang X., Hubbard E.J.A., and Carlson M.: A protein kinase substrate identified by the two-hybrid system. Science 257: 680-2, 1992. IF=32.40; 

  

2. Yang X., Jiang R., and Carlson M.: A family of proteins containing a conserved domain that mediates interaction with the yeast SNF1 protein kinase complex. EMBO J. 13: 5878-86, 1994. IF=10.12; 

  

3. Yang X., Khosravi-Far R., Chang H.Y., and Baltimore D.: Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell 89: 1067-76, 1997. IF=32.40; 

  

4. Chang H.Y., Nishitoh H., Yang X., Ichijo H., and Baltimore D.: Activation of apoptosis signal-regulating Kinase 1 (ASK1) by the adaptor protein Daxx. Science 281: 1860-3, 1998. IF=31.36; 

  

5. Yang X., Chang H.Y., and Baltimore D.: Essential role of CED-4 oligomerization in CED-3 activation and apoptosis. Science 281: 1355-7, 1998. IF=31.36; 

  

6. Yang X., Chang H.Y., and Baltimore D.: Autoproteolytic activation of pro-caspases by oligomerization. Mol Cell 1: 319-25, 1998. IF=14.19; 

  

7. Chang H.Y., Yang X., and Baltimore D.: Dissecting Fas signaling with an altered specificity death domain mutant:  requirement of FADD binding for apoptosis but not JNK activation. Proc Natl Acad Sci U.S.A. 96: 1252-6, 1999. IF=9.78; 

  

8. Chang D.W., Xing Z., Pan Y., Algeciras-Schimnich A., Barnhart B.C., Yaish-Ohad S., Peter M.E., and Yang X.: c-FLIPL is a dual function molecule for caspase-8 activation and CD95-mediated apoptosis. EMBO J. 21: 3704-14, 2002 Notes: Highlighted in Science STKE and Nature Review Immunology. IF=12.10; 

  

9. Chang D.W., Xing Z., Capacio V.L., Peter M.E., and Yang X.: Interdimer processing mechanism of procaspase-8 activation. EMBO J. 22: 4132-42, 2003. IF=12.10; 

  

10. Hu S., Du M.-Q., Park S.-M., Alcivar A., Qu L., Gupta S., Tang J., Baens M., Ye H., Lee T., Marynen P., Riley J.L., and Yang X.: cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas. J Clin Invest. 116: 174-81, 2006 Notes: Commented in this issue. IF=14.20; 

  

11. Tang J., Qu L., Zhang J., Wang W., Michaelson J. S., Degenhardt Y., El-Deiry W.S., and Yang X.: Critical role for Daxx in regulating Mdm2. Nat Cell Biol. 8: 855-62, 2006 Notes: Commented on in this issue. IF=19.40; 

  

12. Kawadler H., Riley J. L., and Yang X.: The paracaspase MALT1 control caspase-8 activation during lymphocyte proliferation. Mol Cell 31: 415-21, 2008 Notes: Highlighted in Science Signaling. IF=14.19; 

  

13. Sun H., Gong S., Hilliard A., Li L., Sun J., Carmody R.J., Kong L., Xu L., Hilliard B., Hu S., DiSpirito J., Shen H., Yang X., and Chen Y.H.: TIPE2, a novel negative regulator of innate and adaptive immunity that maintains immune homeostasis. Cell 133: 415-26, 2008. IF=32.40; 

  

14. Zarnegar B.J., Wang Y., Mahoney D.J., Dempsey P.W., Cheung H.H., He J., Shiba T., Yang X., Yeh W., Mak T.W., Korneluk R. G., and Cheng G.: Activation of noncanonical NF-κB requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2, TRAF3 and the kinase NIK. Nat Immunol. 9: 1371-8, 2008. IF=26.00; 

  

15. Mei Y., Yong J., Liu H., Shi Y., Meinkoth J., Dreyfuss G., and Yang X.: tRNA binds to cytochrome c and inhibits caspase activation. Mol Cell 37: 668-78, 2010 Notes: Cover story and commented on in this issue. Highlighted in Science Signaling and Chemical & Engineering News. IF=14.19; 

  

16. Jiang P., Du W., Wang X., Mancuso A., Gao X., Wu M., and Yang X.: p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nat Cell Biol. 13: 310-18, 2011 Notes: cover story and commented on in this issue. IF=19.40; 

  

17. Li N., Jiang P., Du W., Wu Z., Li C., Qiao M, Yang X. *, and Wu M. * (* corresponding authors): Siva1 suppresses epithelial-mesenchymal transition and metastasis of tumor cells by inhibiting stathmin and stabilizing microtubules. Proc Natl Acad Sci U.S.A. 108: 12851-6, 2011. IF=9.78; 

  

18. Yu J., Jeffrey P., Ha J., Yang X., and Shi Y.: Crystal structure of the MALT1 paracaspase region. Proc Natl Acad Sci U.S.A.  108(52): 201004-9, 2011. IF=9.78; 

  

19. Du W., Jiang P., Stonestrom A., Mak T.W., Wu M., and Yang X: TAp73 enhances the pentose phosphate pathway and supports cell proliferation. Nat Cell Bio 15: 991-1000, 2013 Notes: Cover story and commented on in this issue. IF=19.40; 

  

20. Jiang P., Du W., Mancuso A., Wellen K. and Yang X.: Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature 493: 689-93, 2013. IF=36.28; 

  

21. Guo L., Giasson B.I., Glavis-Bloom A., Brewer M.D., Shorter J., Gitler A.D., and Yang X.: A cellular system that degrades misfolded proteins and protects against neurodegeneration. Mol Cell 55: 15-30, 2014 Notes: Cover story and commented on in this issue. IF=14.19; 

 

Intelligent property 

Yang X., Khosravi-Far R., and Baltimore D.: Daxx, a novel Fas-binding protein that activates JNK and apoptosis. USA Patent Number US Patent 6,159,731, 1998. 

Yang X., Chang H.Y., and Baltimore D.: Chimeric Pro-caspases and Methods of Using Same. USA Patent Number US Patent 6,916,917, 1999. 

Yang X., Mei Y., and Yong J.: Compositions and Methods for Regulating Cytochrome C-Mediated Apoptosis by tRNA. USA Patent Number Provisional Application No. 61/249,115, 2009. 

Yang X. and Guo L: A cellular system that degrades misfolded proteins and protects against neurodegeneration. USA , 2015. 

  

Honor 

  

1983 

  

Decathlon Athlete, Awarded by General Administration of Sport of China 

  

1985 

  

Tsinghua University Outstanding Graduate 

  

1986 

  

Chinese Academy of Sciences Outstanding Graduate Student 

  

1995-1998 

  

The Leukemia & Lymphoma Society Fellow 

  

2004-2009 

  

The Leukemia & Lymphoma Society Scholar 

  

2007-2008 

  

R. Robert and Sally D. Funderburg Research Scholar Award in Gastric Biology Related to Cancer,
American Gastroenterology Association 

  

2007-2010 

  

Outstanding Overseas Young Scientist
National Nature Science Foundation of China 

  

Email Phone:075586585202, 18318069286,yangxl@siat.ac.cn;