Smart Indocyanine Green Nanoprobe for Imaging-Guided Cancer Synergistic Phototherapy
Phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), is a light-activated treatment modality that is under intensive preclinical and clinical investigations for cancer therapy. To enhance the treatment efficiency of phototherapy and reduce the light-associated side effects, it is highly desirable to improve drug accumulation and precision guided phototherapy for efficient conversion of the absorbed light energy to reactive oxygen species (ROS) and hyperthermia.
A research group led by Prof LintaoCai at Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,developed an a programmed assembly strategy using the human serum albumin (HSA)-indocyanine green (ICG) nanoprobes for imaging-guided cancer synergistic phototherapy. They found that the prepared HAS-ICG nanoprobes had a high tumor accumulation ratio and a long-term retention time in 4T1 tumor-bearing mice model.The tumor and its margin were clearly identified via ICG-based in vivo near-infrared (NIR) fluorescence and photoacoustic dual-modal imaging and spectrum-resolved technology. Meanwhile, the HAS-ICGnanoprobe efficiently induced ROS and local hyperthermia simultaneously for synergetic PDT/PTT treatments, and the tumor was completely suppressed without recurrence under a single NIR laser irradiation for 5 min.The studies are highly potential for imaging-guided cancer phototherapy with PDT/PTT synergistic effects.These results were published in ACS Nano(2014, 8(12),12310–12322)
The work was supported by the NationalNatural Science Foundation of China, Key Project of Science and Technologyof Guangdong and Shenzhen, Guangdong Innovation Team of Low-cost Healthcare,and SIAT Innovation Program for Excellent Young Researchers.
Schematic illustration of HSA-ICG nanoprobesgenerated by programmed assemblyfor in vivo dual-modal imaging, tumor margin detection, and simultaneousPDT/PTT treatments.
Key words:indocyanine green,theranostics,photothermal therapy, photodynamic therapy, synergistic effect, photoacoustic imaging.
Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy ofSciences, PR China.
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