Researchers Established a Simple Method for Synthesis of Ultrathin Bi2Se3 Nanosheets

Photothermal therapy based on tissue-transparent near-infrared (NIR) light has been gaining clinical acceptance in cancer treatment due to the specific spatial/temporal selectivity and minimal invasiveness.  

Prof. Yu Xuefeng from Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, and his collaborators successfully synthesized the ultrathin Bi2Se3 nanosheets with a thickness of 1.7 nm and diameter of 31.4 nm by a solution-based method. This method to successfully synthesize the ultrathin Bi2Se3 nanosheets and used as an efficient NIR-triggered theranostic agent. Such ultrathin Bi2Se3 nanosheets possess an extinction coefficient of 11.5 Lg-1cm-1 at 808 nm, boast a high PT conversion efficiency of 34.6% and also deliver excellent photoacoustic performance, enabling efficient imaging-guided photothermal therapy. Furthermore, these ultrathin Bi2Se3 nanosheets are well metabolized. These attractive properties render the ultrathin Bi2Se3 nanosheets promising as a NIR-triggered theranostic agents in cancer therapies. 

The paper “Metabolizable Ultrathin Bi2Se3 Nanosheets in Imaging-Guided Photothermal Therapy” was published in the latest issue of Small as the “Back Cover”.   

This work is supported by the Science and Technology Key Projects of Shenzhen and Hong Kong Research Grants Council (RGC) General Research Funds (GRF) 


Fig1. Transmission electron microscopy image of the Bi2Se3 nanosheets (a); In vivo photoacoustic imaging of  the Bi2Se3 nanosheets (b); In vivo biodistribution and clearance of the Bi2Se3 nanosheets in different organs (c); In vivo photothermal therapy (d).  


Fig2. Cover image of Small 

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