Researchers Find Lung Distribution of Antivirals Matters in COVID-19 Treatment
Coronavirus Disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has killed over 1,000,000 people around the world. It is impossible to create novel drugs against the coronavirus in a very short time, as this often takes years. Therefore the best strategy is to find new antiviral uses from approved drugs.
Lopinavir, for example, originally approved as an anti-HIV drug, was reported to benefit SARS patients 17 years ago. However, it fails to reduce SARS-CoV-2 viral loads in COVID-19 patients though lopinavir significantly inhibit SARS-CoV-2 replication in vitro.
The previous result, which was published on British Journal of Pharmacology, from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences proposed that anti-SARS-CoV-2 drug repurposing studies should pay more attentions to the lung tissue distribution of antiviral drugs.
Recently, the team collaborated with Rutgers University compared pharmacokinetics profiles of these drugs and their capabilities of reducing viral load in clinical trials. The work was published on European Journal of Pharmacology in October 6.
According to bulk RNA and single cell RNA sequencing analysis, the team found that high expression of both angiotensin converting enzyme 2 (ACE2) and transmembrane Serine Protease 2 (TMPRSS2) made the lung and intestine vulnerable to SARS-CoV-2. Hydroxychloroquine, chloroquine and favipiravir, which were highly distributed to the lung, were reported to reduce viral loads in respiratory tract of COVID-19 patients. Conversely, drugs with poor lung distributions, including lopinavir/ritonavir, umifenovir and remdesivir, were insufficient to inhibit viral replication.
This work might explain why some strong antivirals did not benefit the patients with COVID-19. The antiviral drugs should be distributed straight to the lung tissue for reducing viral loads in respiratory tract of COVID-19 patients.
Comparison of the pharmacokinetics profiles of drugs and their capabilities of reducing viral load in clinical trials. (Image by SIAT)